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Invitrogen

TGFBR3 Polyclonal Antibody

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View all (20) TGFBR3 antibodies

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Product Details

PA5-17529

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunoprecipitation (IP)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues in the extracellular domain of the type III TGF-β receptor

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

120.8 µg/mL

Amount

12.08 µg

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11001447

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with other family members at physiological conditions.

Target Information

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Betaglycan; betaglycan proteoglycan; OTTHUMP00000011787; tgf beta receptor 3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; unnamed protein product

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Gene Aliases: 1110036H20Rik; AU015626; AW215636; betaglycan; BGCAN; TBRIII; TGFBR3

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UniProt ID: (Human) Q03167, (Mouse) O88393

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Entrez Gene ID: (Human) 7049, (Mouse) 21814

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Function(s)
transmembrane signaling receptor activity transforming growth factor beta-activated receptor activity type II transforming growth factor beta receptor binding transforming growth factor beta receptor binding protein binding glycosaminoglycan binding heparin binding coreceptor activity fibroblast growth factor binding PDZ domain binding BMP binding SMAD binding activin binding transforming growth factor beta binding transforming growth factor beta receptor activity, type III transmembrane signal receptor
Process(es)
response to hypoxia epithelial to mesenchymal transition liver development heart morphogenesis muscular septum morphogenesis outflow tract morphogenesis ventricular compact myocardium morphogenesis immune response transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor complex assembly positive regulation of gene expression cell migration regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell migration BMP signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway organ regeneration response to follicle-stimulating hormone response to prostaglandin E response to luteinizing hormone intracellular signal transduction negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of JNK cascade negative regulation of epithelial cell proliferation ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation definitive hemopoiesis cardiac epithelial to mesenchymal transition definitive erythrocyte differentiation heart trabecula formation positive regulation of SMAD protein import into nucleus negative regulation of SMAD protein import into nucleus ventricular septum morphogenesis epicardium-derived cardiac fibroblast cell development vasculogenesis involved in coronary vascular morphogenesis heart trabecula morphogenesis secondary palate development protein-containing complex assembly regulation of ERK1 and ERK2 cascade cellular response to transforming growth factor beta stimulus positive regulation of cell migration involved in sprouting angiogenesis positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of extracellular matrix assembly blood vessel development vasculogenesis osteoblast differentiation in utero embryonic development blastocyst development blood vessel remodeling epicardial cell to mesenchymal cell transition protein complex assembly protein phosphorylation positive regulation of cell proliferation embryo development negative regulation of epithelial cell migration negative regulation of epithelial to mesenchymal transition cell growth positive regulation of BMP signaling pathway regulation of protein binding regulation of blood vessel size positive regulation of NF-kappaB transcription factor activity negative regulation of cellular component movement palate development pathway-restricted SMAD protein phosphorylation coronary vasculature development coronary vasculature morphogenesis visceral serous pericardium development negative regulation of apoptotic process involved in morphogenesis
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