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Invitrogen
MARK4 Polyclonal Antibody
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Product Details
PA5-18025
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (IKRKPPPGCSDSPGV) corresponding to the C-terminus amino acids of MARK4 (aa 674-688).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
MARK4 is a serine/threonine kinase that is likely to be directly involved in microtubule organization in neuronal cells. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of MARK4 is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of MARK4 are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for MARK4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ90097; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4 serine/threonine protein kinase; Nbla00650; unnamed protein product
Gene Aliases: 2410090P21Rik; C79806; KIAA1860; MARK4; MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D
UniProt ID: (Human) Q96L34, (Mouse) Q8CIP4
Entrez Gene ID: (Human) 57787, (Mouse) 232944
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
microtubule binding
cytoskeletal adaptor activity
kinase activity
transferase activity
gamma-tubulin binding
ubiquitin binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
microtubule bundle formation
protein phosphorylation
nervous system development
cell projection organization
intracellular signal transduction
positive regulation of programmed cell death
cilium organization
positive regulation of cilium assembly
positive regulation of cell cycle
regulation of centrosome cycle
microtubule polymerization
cell division
cilium disassembly
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of protein localization to centrosome
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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