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Invitrogen
HNF4A Polyclonal Antibody
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FIGURE: 1 / 2
HNF4A Antibody (PA5-18363) in IHC (P)
Immunohistochemistry analysis of HNF4A in human small intestine. Samples were incubated with HNF4A polyclonal antibody (Product # PA5-18363) using a dilution of 2 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18363
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (RLSKTLVDMDMADY) corresponding to the N-terminus amino acids of HNF4A (aa 2-15).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine and porcine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is an orphan nuclear receptor. HNF4a is expressed in the liver, kidney, intestine, and pancreas. Mutation of HNF4a in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4a gene is alternatively spliced and may generate up to nine different isoforms, HNF4a1 through HNF4a9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ39654; hepatic nuclear factor 4 alpha; Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4-alpha; HNF4A wild type; HNF4a7; HNF4a8; HNF4a9; HNF4alpha10/11/12; Nuclear receptor subfamily 2 group A member 1; TCF-14; transcription factor; Transcription factor 14; Transcription factor HNF-4
Gene Aliases: FRTS4; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF-14; TCF14
UniProt ID: (Human) P41235
Entrez Gene ID: (Human) 3172
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
receptor binding
fatty acid binding
protein binding
zinc ion binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
lipid metabolic process
xenobiotic metabolic process
sex differentiation
blood coagulation
negative regulation of cell proliferation
response to glucose
gene expression
regulation of gastrulation
regulation of lipid metabolic process
signal transduction involved in regulation of gene expression
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
glucose homeostasis
cholesterol homeostasis
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
regulation of insulin secretion
lipid homeostasis
phospholipid homeostasis
regulation of growth hormone receptor signaling pathway
triglyceride homeostasis
regulation of ornithine metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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