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Invitrogen
Kir6.2 (KCNJ11) Polyclonal Antibody
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FIGURE: 1 / 2
Kir6.2 (KCNJ11) Antibody (PA5-18710) in IHC (P)
Immunohistochemistry analysis of Kir6.2 (KCNJ11) in human pancreas. Samples were incubated with Kir6.2 (KCNJ11) polyclonal antibody (Product # PA5-18710) using a dilution of 75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (AEDPAKPRYRARQ) corresponding to the internal amino acids of KCNJ11 (aa 18-23).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; beta-cell inward rectifier subunit; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifing potassium channel subfamily J member 11; inwardly rectifying potassium channel KIR6.2; inwardly-rectifying potassium channel subfamily J member 11; IRK11; KATP; KATP channel; MGC133230; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium voltage-gated channel subfamily J member 11; unnamed protein product
Gene Aliases: BIR; HHF2; IKATP; KCNJ11; KIR6.2; MODY13; PHHI; PNDM2; TNDM3
UniProt ID: (Human) Q14654
Entrez Gene ID: (Human) 3767
nucleotide binding
inward rectifier potassium channel activity
voltage-gated potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
cation-transporting ATPase activity
ankyrin binding
potassium ion binding
ion channel binding
metal ion binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
action potential
response to hypoxia
response to ischemia
ventricular cardiac muscle tissue development
glucose metabolic process
ion transport
potassium ion transport
apoptotic process
response to stress
determination of adult lifespan
response to xenobiotic stimulus
cellular response to nutrient levels
response to ATP
ion transmembrane transport
regulation of ion transmembrane transport
regulation of membrane potential
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
CAMKK-AMPK signaling cascade
potassium ion transmembrane transport
inorganic cation transmembrane transport
regulation of presynaptic membrane potential
response to resveratrol
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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