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Invitrogen
TACR1 Polyclonal Antibody
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FIGURE: 1 / 2
TACR1 Antibody (PA5-18712) in ICC/IF
Immunocytochemistry analysis of TACR1 using TACR1 Polyclonal Antibody (Product # PA5-18712) in paraformaldehyde fixed Neuro2a cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and plasma membrane staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
Product Details
PA5-18712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (EIPGDSSDRYHEQ) corresponding to the internal amino acids of TACR1 (aa 227-240).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; substance P receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor); unnamed protein product
Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1
UniProt ID: (Human) P25103, (Mouse) P30548
Entrez Gene ID: (Human) 6869, (Mouse) 21336
aggressive behavior
positive regulation of leukocyte migration
angiotensin-mediated drinking behavior
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
learning or memory
long-term memory
regulation of blood pressure
associative learning
detection of abiotic stimulus
response to hormone
response to ozone
positive regulation of epithelial cell migration
response to auditory stimulus
regulation of smooth muscle cell migration
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to estradiol
response to progesterone
response to nicotine
operant conditioning
sperm ejaculation
eating behavior
positive regulation of vascular permeability
response to ethanol
positive regulation of action potential
positive regulation of blood pressure
positive regulation of ossification
positive regulation of vasoconstriction
positive regulation of hormone secretion
response to pain
behavioral response to pain
regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of epithelial cell proliferation
positive regulation of stress fiber assembly
response to electrical stimulus
smooth muscle contraction involved in micturition
regulation of uterine smooth muscle contraction
positive regulation of uterine smooth muscle contraction
positive regulation of sperm motility
neuropeptide signaling pathway
chemical synaptic transmission
response to heat
response to organic cyclic compound
sensory perception of pain
positive regulation of renal sodium excretion
positive regulation of saliva secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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