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Invitrogen

NRXN1 Polyclonal Antibody

View all (23) NRXN1 antibodies

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Product Details

PA5-18730

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1 µg/mL
-

Flow Cytometry (Flow)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (KEKQPSSAKSSNKN) corresponding to the C-terminus amino acids of NRXN1 (aa 449-463).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10983959

Product Specific Information

This antibody is expected to recognize both reported isoforms (NP_004792.1 and NP_620072.1).

It is predicted to react with canine, mouse and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Target Information

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp313P2036; FLJ35941; Neurexin 1alpha; neurexin I; Neurexin I-alpha; Neurexin I-beta; Neurexin-1; Neurexin-1-alpha; Neurexin-1-beta; neuronal cell surface protein; unnamed protein product

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Gene Aliases: Hs.22998; KIAA0578; NRXN1; PTHSL2; SCZD17

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UniProt ID: (Human) Q9ULB1

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Entrez Gene ID: (Human) 9378

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Function(s)
transmembrane signaling receptor activity receptor binding type 1 fibroblast growth factor receptor binding calcium channel regulator activity calcium ion binding protein binding acetylcholine receptor binding signaling receptor activity metal ion binding calcium-dependent protein binding cell adhesion molecule binding neuroligin family protein binding
Process(es)
angiogenesis cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion signal transduction chemical synaptic transmission neurotransmitter secretion axon guidance synapse assembly learning positive regulation of gene expression negative regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cerebellar granule cell differentiation neuronal signal transduction adult behavior neuron projection development positive regulation of synaptic transmission, GABAergic social behavior protein localization to synapse vocal learning positive regulation of cAMP-mediated signaling establishment of protein localization positive regulation of fibroblast growth factor receptor signaling pathway neuron projection morphogenesis neuromuscular process controlling balance negative regulation of filopodium assembly positive regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion vocalization behavior protein complex assembly involved in synapse maturation positive regulation of synapse maturation synaptic vesicle clustering postsynaptic membrane assembly presynaptic membrane assembly gamma-aminobutyric acid receptor clustering NMDA glutamate receptor clustering gephyrin clustering involved in postsynaptic density assembly guanylate kinase-associated protein clustering neuroligin clustering involved in postsynaptic membrane assembly postsynaptic density protein 95 clustering receptor localization to synapse NMDA selective glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway positive regulation of neuromuscular synaptic transmission positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of protein localization to plasma membrane positive regulation of presynaptic active zone assembly positive regulation of excitatory postsynaptic potential
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