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Invitrogen
RAB8A Polyclonal Antibody
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Product Details
PA5-18875
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (NQGVKITPDQQKR) corresponding to the C-terminus amino acids of RAB8A (aa 186-199).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine and canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); Oncogene c-mel; RAB8A; ras-associated protein RAB8; Ras-related protein Rab-8A; unnamed protein product
Gene Aliases: MEL; RAB8; RAB8A
UniProt ID: (Human) P61006
Entrez Gene ID: (Human) 4218
exocytosis
vesicle docking involved in exocytosis
autophagy
Golgi organization
axonogenesis
regulation of autophagy
protein transport
cell projection organization
endocytic recycling
cellular response to insulin stimulus
regulation of protein localization
regulation of long-term neuronal synaptic plasticity
Golgi vesicle fusion to target membrane
regulation of protein transport
cilium morphogenesis
protein localization to cilium
protein localization to plasma membrane
neurotransmitter receptor transport, endosome to postsynaptic membrane
neurotransmitter receptor transport to postsynaptic membrane
vesicle-mediated transport in synapse
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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