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Invitrogen
CES1 Polyclonal Antibody
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FIGURE: 1 / 7
CES1 Antibody (PA5-19740) in ICC/IF
Immunofluorescence analysis of CES1 was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with CES1 Polyclonal Antibody (Product # PA5-19740) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A2703... View More
Product Details
PA5-19740
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 500 to the C-terminus of Human Liver Carboxylesterase 1.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with baboon and rhesus monkey based on sequence homology.
Store antibody at 4°C for 1-2 weeks. For long-term storage, store at -20°C.
Target Information
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACAT; acyl coenzyme A:cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxyesterase ES-1; carboxyesterase ES-3; Carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 1-like; Carboxylesterase 1C; Carboxylesterase 1E; Carboxylesterase 1G; carboxylesterase 2 (liver); carboxylesterase; ACAT; CE-1; CEH; Cholesteryl ester hydrolase; Cocaine carboxylesterase; E1; Egasyn; ER-resident carboxylesterase; Es-22; ES-HTEL; ES-THET; ES-x; esterase 1; Esterase 2 member of carboxylesterase-cluster 1; esterase 2, member of carboxylesterase-cluster 1; esterase 22; Esterase-2; esterase-22; HMSE; human monocyte/macrophage serine esterase 1; Liver carboxylesterase 1; Liver carboxylesterase 22; liver carboxylesterase 3; Liver carboxylesterase N; Lung surfactant convertase; Methylumbelliferyl-acetate deacetylase 1; MGC117365; Monocyte/macrophage serine esterase; Neutral retinyl ester hydrolase; NREH; PES-N; pI 5.5 esterase; REH; Retinyl ester hydrolase; Serine esterase 1; TGH; triacylglycero; Triacylglycerol hydrolase; unnamed protein product
Gene Aliases: ACAT; CE-1; CEH; Ces-1; Ces-N; CES1; Ces1c; Ces1e; Ces1g; Ces1l; CES2; Ee-1; Ee1; Eg; EG244595; egasyn; Es-22; Es-4; Es-N; Es1; Es2; Es22; Es4; EsN; Gm4976; hCE-1; HMSE; HMSE1; PCE-1; PESN; REH; Ses-1; SES1; TGH
UniProt ID: (Human) P23141, (Mouse) P23953, (Rat) P10959, (Mouse) Q64176, (Mouse) Q8VCC2
Entrez Gene ID: (Human) 1066, (Rat) 679817, (Mouse) 244595, (Mouse) 13884, (Rat) 24346, (Rat) 29225, (Mouse) 13897, (Mouse) 12623
lipid metabolic process
cholesterol biosynthetic process
cholesterol metabolic process
response to toxic substance
positive regulation of cholesterol efflux
negative regulation of cholesterol storage
lipid catabolic process
epithelial cell differentiation
cholesterol homeostasis
reverse cholesterol transport
medium-chain fatty acid metabolic process
regulation of bile acid biosynthetic process
cellular response to cholesterol
cellular response to low-density lipoprotein particle stimulus
cholesterol ester hydrolysis involved in cholesterol transport
positive regulation of cholesterol metabolic process
regulation of bile acid secretion
metabolic process
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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