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Invitrogen
TEM8 Polyclonal Antibody
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Product Details
PA5-20017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 13 amino acids near the C-terminus of human TEM8.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Ion-exchange chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is K562 cell lysate.
PA5-20017 can be used with blocking peptide PEP-0136.
Target Information
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; ATR; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8; unnamed protein product
Gene Aliases: 2310008J16Rik; 2810405N18Rik; Antrx1; ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2, (Rat) Q0PMD2, (Mouse) Q9CZ52
Entrez Gene ID: (Human) 84168, (Rat) 362393, (Mouse) 69538
blood vessel development
epidermal growth factor receptor signaling pathway
actin cytoskeleton organization
substrate adhesion-dependent cell spreading
positive regulation of epidermal growth factor receptor signaling pathway
negative regulation of extracellular matrix assembly
signal transduction
biological_process
reproductive process
actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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