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Invitrogen
Caspase 4 Polyclonal Antibody
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Product Details
PA5-20109
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide from near the center of human Caspase-4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-20109 can be used with blocking peptide PEP-0227.
Target Information
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; Mih1; propeptide of Mih1/TX; protease ICH-2; Protease TX; unnamed protein product
Gene Aliases: CASP4; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1; Mih1/TX; TX
UniProt ID: (Human) P49662
Entrez Gene ID: (Human) 837
immune system process
proteolysis
apoptotic process
inflammatory response
protein secretion
programmed cell death
protein autoprocessing
interleukin-18-mediated signaling pathway
defense response to bacterium
regulation of apoptotic process
positive regulation of neuron apoptotic process
NLRP3 inflammasome complex assembly
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
defense response to Gram-positive bacterium
protein maturation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
pyroptosis
intrinsic apoptotic signaling pathway
pyroptotic cell death
non-canonical inflammasome complex assembly
positive regulation of tumor necrosis factor-mediated signaling pathway
cellular response to beta-amyloid
positive regulation of interleukin-18-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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