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Invitrogen
TLR6 Polyclonal Antibody
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Product Details
PA5-20188
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 13 amino acids near the center of human TLR6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Jurkat cell lysate.
PA5-20188 can be used with blocking peptide PEP-0318.
Target Information
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 286; CD286; Toll-like receptor 6; unnamed protein product
Gene Aliases: CD286; TLR6
UniProt ID: (Human) Q9Y2C9
Entrez Gene ID: (Human) 10333
beta-amyloid binding
transmembrane signaling receptor activity
receptor binding
protein binding
Toll-like receptor 2 binding
signaling receptor activity
diacyl lipopeptide binding
identical protein binding
protein heterodimerization activity
NAD+ nucleotidase, cyclic ADP-ribose generating
lipopeptide binding
microglial cell activation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
positive regulation of gene expression
response to bacterial lipoprotein
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
negative regulation of toll-like receptor 2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
detection of diacyl bacterial lipopeptide
defense response to bacterium
positive regulation of macrophage activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
innate immune response
positive regulation of nitric oxide biosynthetic process
nitric oxide metabolic process
positive regulation of inflammatory response
cellular response to diacyl bacterial lipopeptide
cellular response to oxidised low-density lipoprotein particle stimulus
positive regulation of cytokine production involved in inflammatory response
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of reactive oxygen species biosynthetic process
cellular response to beta-amyloid
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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