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Invitrogen
Cullin 9 Polyclonal Antibody
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Product Details
PA5-20277
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide from near the carboxy terminus of human PARC.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Daudi cell lysate.
PA5-20277 can be used with blocking peptide PEP-0354.
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CUL-9; Cullin-9; E3 ligase; KIAA0708; p53-associated parkin-like cytoplasmic protein; parkin-like cytoplasmic p53 binding protein; RP3-330M21.2; UbcH7-associated protein 1; unnamed protein product
Gene Aliases: 1810035I07Rik; Cul-9; CUL9; H7AP1; KIAA0708; mKIAA0708; PARC
UniProt ID: (Human) Q8IWT3, (Mouse) Q80TT8
Entrez Gene ID: (Human) 23113, (Mouse) 78309
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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