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Invitrogen

Nogo-A Polyclonal Antibody

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Nogo-A Polyclonal Antibody

Product Details

PA5-20366

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1 µg/mL
-

Immunohistochemistry (IHC)

2.5 µg/mL
-

Immunocytochemistry (ICC/IF)

2.5 - 20 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 23 amino acid peptide from near the amino terminus of human NogoA.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11155169

Product Specific Information

Despite its predicted molecular weight, NogoA typically migrates at 180kDa in an SDS-PAGE. A suggested positive control is mouse brain tissue lysate.

PA5-20366 can be used with blocking peptide PEP-0480.

Target Information

NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASY; Foocen; Glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI-220/250; Nogo protein; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; NSP; reticulon; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product

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Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI-250; NI220/250; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP; NSP-CL; r; rat N; rat NogoA; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507; Vp20

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UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72, (Rat) Q9JK11

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Entrez Gene ID: (Human) 57142, (Mouse) 68585, (Rat) 83765

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Function(s)
RNA binding protein binding ubiquitin protein ligase binding protein homodimerization activity cadherin binding metal ion binding protein complex binding poly(A) RNA binding
Process(es)
angiogenesis nervous system development axonogenesis axonal fasciculation negative regulation of neuron projection development cerebral cortex radial glia guided migration negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of dopamine secretion negative regulation of neuron differentiation positive regulation of glial cell differentiation negative regulation of axonogenesis regulation of sensory perception of pain regulation of nervous system development cardiac epithelial to mesenchymal transition negative regulation of neuron projection regeneration endoplasmic reticulum tubular network organization regulation of branching morphogenesis of a nerve blastocyst formation leukocyte migration involved in inflammatory response apoptotic process endoplasmic reticulum organization brain development positive regulation of epithelial cell migration central nervous system vasculogenesis neuron differentiation positive regulation of mammary gland epithelial cell proliferation positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis regulation of apoptotic process positive regulation of angiogenesis modulation of synaptic transmission protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein localization to lysosome cellular response to hypoxia endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis cell adhesion involved in sprouting angiogenesis regulation of postsynapse assembly negative regulation of beta-amyloid formation positive regulation of neutrophil migration positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis endoplasmic reticulum tubular network membrane organization positive regulation of hepatocyte proliferation negative regulation of vasculogenesis aging response to activity olfactory nerve development oligodendrocyte differentiation
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