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Invitrogen

ACVR1 Polyclonal Antibody

View all (18) ACVR1 antibodies

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ACVR1 Polyclonal Antibody

Product Details

PA5-20604

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 14 amino acid peptide near the amino terminus of the human ACVR1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11155773

Product Specific Information

A suggested positive control is A549 cell lysate.

PA5-20604 can be used with blocking peptide PEP-0724.

Target Information

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR-I; ALK-2; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I; unnamed protein product

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Gene Aliases: ActR-I; ACTRI; ActRIA; Acvr; ACVR1; ACVR1A; ACVRLK2; Alk-2; ALK2; Alk8; D330013D15Rik; FOP; SKR1; Tgfb1; Tsk7L; TSRI

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UniProt ID: (Human) Q04771, (Mouse) P37172

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Entrez Gene ID: (Human) 90, (Mouse) 11477

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I protein binding ATP binding kinase activity activin receptor activity, type I transferase activity peptide hormone binding growth factor binding protein homodimerization activity cadherin binding SMAD binding metal ion binding activin binding transforming growth factor beta binding BMP receptor activity protein tyrosine kinase binding receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
patterning of blood vessels osteoblast differentiation in utero embryonic development gastrulation with mouth forming second mesoderm formation neural crest cell migration acute inflammatory response embryonic heart tube morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis mitral valve morphogenesis endocardial cushion formation endocardial cushion fusion atrial septum primum morphogenesis transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry gastrulation mesoderm development heart development dorsal/ventral pattern formation negative regulation of signal transduction cell differentiation regulation of ossification positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway endothelial cell differentiation positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation positive regulation of multicellular organismal process pharyngeal system development positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis epithelial tube morphogenesis cardiac muscle cell fate commitment endocardial cushion cell fate commitment positive regulation of cardiac epithelial to mesenchymal transition cellular response to growth factor stimulus cellular response to BMP stimulus circulatory system development positive regulation of intracellular signal transduction positive regulation of determination of dorsal identity regulation of multicellular organismal development negative regulation of G1/S transition of mitotic cell cycle negative regulation of extrinsic apoptotic signaling pathway G1/S transition of mitotic cell cycle urogenital system development protein phosphorylation embryo development positive regulation of pathway-restricted SMAD protein phosphorylation phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation intracellular signal transduction pathway-restricted SMAD protein phosphorylation
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