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Invitrogen
ZC3H8 Polyclonal Antibody
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Product Details
PA5-21811
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ZC3H8. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.84 mg/mL
Amount
84 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: contains charged domain; Zinc finger CCCH domain-containing protein 8; zinc finger CCCH-type domain containing 8
Gene Aliases: Fliz1; ZC3H8; ZC3HDC8
UniProt ID: (Human) Q8N5P1
Entrez Gene ID: (Human) 84524
negative regulation of transcription from RNA polymerase II promoter
apoptotic process
negative regulation of T cell differentiation in thymus
snRNA transcription from RNA polymerase II promoter
snRNA transcription from RNA polymerase III promoter
T cell homeostasis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase III promoter
response to antibiotic
positive regulation of thymocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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