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Invitrogen
Villin Polyclonal Antibody
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Product Details
PA5-22072
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cat,
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human Villin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.31 mg/mL
Amount
131 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HepG2, mouse kidney, rat kidney.
Predicted reactivity: Mouse (89%), Rat (89%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Villin is part of cytoskeleton associated with the microvillar actin core bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: OTTHUMP00000207159; unnamed protein product; Villin-1
Gene Aliases: D2S1471; VIL; VIL1
UniProt ID: (Human) P09327, (Mouse) Q62468
Entrez Gene ID: (Human) 7429, (Dog) 488522, (Mouse) 22349, (Rat) 316521
actin binding
calcium ion binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
lysophosphatidic acid binding
identical protein binding
protein homodimerization activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
actin filament binding
metal ion binding
molecular_function
non-motor actin binding protein
intestinal D-glucose absorption
apoptotic process
cytoskeleton organization
actin filament organization
epidermal growth factor receptor signaling pathway
actin polymerization or depolymerization
regulation of cell shape
response to bacterium
positive regulation of epithelial cell migration
actin filament polymerization
actin filament depolymerization
positive regulation of cell migration
positive regulation of actin filament depolymerization
epithelial cell differentiation
positive regulation of actin filament bundle assembly
regulation of microvillus length
cellular response to hepatocyte growth factor stimulus
positive regulation of multicellular organism growth
positive regulation of cellular component biogenesis
actin filament severing
barbed-end actin filament capping
regulation of actin nucleation
actin filament capping
cytoplasmic actin-based contraction involved in cell motility
regulation of wound healing
protein-containing complex assembly
cellular response to epidermal growth factor stimulus
positive regulation of lamellipodium organization
terminal web assembly
positive regulation of protein localization to plasma membrane
regulation of lamellipodium morphogenesis
positive regulation of lamellipodium morphogenesis
microvillus assembly
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
actin nucleation
positive regulation of establishment of protein localization to plasma membrane
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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