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Invitrogen
PEX19 Polyclonal Antibody
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FIGURE: 1 / 14
PEX19 Antibody (PA5-22129) in ICC/IF
Immunofluorescence analysis of PEX19 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with PEX19 Rabbit Polyclonal Antibody (Product # PA5-22129) at 5 µg/mL in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at... View More
Product Details
PA5-22129
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PEX19. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Amount
101 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Jurkat, Raji, NCI-H929, K562, THP-1, HL-60, mouse liver, PC-12, Rat-2.
Predicted reactivity: Mouse (91%), Rat (93%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 33 kDa housekeeping protein; housekeeping gene, 33kD; Peroxin-19; Peroxisomal biogenesis factor 19; Peroxisomal farnesylated protein; peroxisome biogenesis factor 19; PEX19; PxF; unnamed protein product
Gene Aliases: D1S2223E; HK33; OK/SW-cl.22; PBD12A; PEX19; PMP1; PMPI; PXF; PXMP1
UniProt ID: (Human) P40855, (Mouse) Q8VCI5
Entrez Gene ID: (Human) 5824, (Mouse) 19298, (Rat) 289233
protein folding
protein targeting to peroxisome
peroxisome organization
peroxisome membrane biogenesis
peroxisome fission
protein import into peroxisome membrane
protein stabilization
establishment of protein localization to peroxisome
negative regulation of lipid binding
chaperone-mediated protein folding
chaperone-mediated protein transport
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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