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Invitrogen
PPP3CB Polyclonal Antibody
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Product Details
PA5-22148
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 228 of PPP3CB (Uniprot ID#P16298)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa, Molt-4, mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (83%), Xenopus laevis (83%), Rabbit (99%), Chicken (96%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PPP3CB is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcineurin A beta; calcineurin A1; calcineurin A2; Calmodulin-dependent calcineurin A subunit beta isoform; CAM-PRP catalytic subunit; CNA beta; PP2BA beta; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase from PCR fragment H32; RP11-345K20.1; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; unnamed protein product
Gene Aliases: 1110063J16Rik; CALNA2; CALNB; CNA2; Cnab; CnAbeta; PP2Bbeta; PPP3CB
UniProt ID: (Human) P16298, (Mouse) P48453
Entrez Gene ID: (Human) 5532, (Mouse) 19056
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
calcium ion binding
protein binding
calmodulin binding
hydrolase activity
enzyme binding
protein phosphatase 2B binding
calmodulin-dependent protein phosphatase activity
metal ion binding
protein dimerization activity
calcium-dependent protein serine/threonine phosphatase activity
drug binding
protein heterodimerization activity
protein phosphatase
T cell mediated cytotoxicity
negative regulation of T cell mediated cytotoxicity
lymphangiogenesis
protein phosphorylation
protein dephosphorylation
response to stress
lysosome organization
signal transduction
heart development
learning
memory
regulation of gene expression
dephosphorylation
calcium ion regulated exocytosis
negative regulation of signaling
T cell differentiation
locomotion involved in locomotory behavior
calcineurin-NFAT signaling cascade
response to cytokine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T cell proliferation
T cell activation
T cell homeostasis
negative regulation of innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
axon extension
skeletal muscle fiber development
regulation of insulin secretion
positive regulation of calcineurin-NFAT signaling cascade
calcineurin-mediated signaling
antibacterial innate immune response
negative regulation of protein localization to nucleus
positive regulation of protein localization to nucleus
regulation of synaptic vesicle endocytosis
positive regulation of calcium ion import across plasma membrane
positive regulation of lysosome organization
negative regulation of calcium ion import across plasma membrane
cellular response to drug
positive regulation of NFAT protein import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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