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Invitrogen
cGKI Polyclonal Antibody
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Product Details
PA5-22182
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human cGK1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: JC, BCL-1.
Predicted reactivity: Mouse (99%), Rat (99%), Japanese Medaka (84%), Pig (99%), Rabbit (98%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGK 1; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1; unnamed protein product
Gene Aliases: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; PKG1; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Human) Q13976, (Mouse) P0C605
Entrez Gene ID: (Human) 5592, (Mouse) 19091
nucleotide binding
catalytic activity
protein kinase activity
protein serine/threonine kinase activity
cGMP-dependent protein kinase activity
calcium channel regulator activity
protein binding
ATP binding
kinase activity
transferase activity
cGMP binding
identical protein binding
mitogen-activated protein kinase p38 binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
non-receptor serine/threonine protein kinase
neuron migration
protein phosphorylation
signal transduction
positive regulation of cytosolic calcium ion concentration
spermatid development
heart development
negative regulation of inositol phosphate biosynthetic process
negative regulation of glutamate secretion
negative regulation of smooth muscle cell migration
dendrite development
cGMP-mediated signaling
cerebellum development
actin cytoskeleton organization
forebrain development
vasodilation
positive regulation of circadian rhythm
regulation of GTPase activity
regulation of vascular permeability
negative regulation of smooth muscle contraction
collateral sprouting
relaxation of vascular smooth muscle
cell growth involved in cardiac muscle cell development
negative regulation of platelet aggregation
bone growth
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
regulation of testosterone biosynthetic process
metabolic process
phosphorylation
negative regulation of heart contraction
positive regulation of vasodilation
mitophagy in response to mitochondrial depolarization
positive regulation of large conductance calcium-activated potassium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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