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Invitrogen
LGR7 Polyclonal Antibody
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FIGURE: 1 / 2
LGR7 Antibody (PA5-23227) in IHC (P)
Immunohistochemical analysis of LGR7 in formalin-fixed paraffin-embedded adenocarcinoma of the stomach (IMH-343). Samples were incubated in LGR7 polyclonal antibody (Product # PA5-23227) using a dilution of 1:50 followed by a peroxidase-conjugate and DAB chromogen. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooli... View More
Product Details
PA5-23227
Product Specifications
Species Reactivity
Dog,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Within the range of amino acids 694-732 of human RXFP1 protein.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 50% glycerol
Contains
0.025% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence homology: horse/bovine/dog/cat (83%).
Target Information
LGR7 is a low density lipoprotein receptor of 757amino acid belonging to the G-protein coupled receptor 1 family with rhodopsin-like receptor activity. It has seven transmembrane region, cysteine-rich motif, 10 LRR domains and 5 N-glycosylation sites in the N terminus. Research reports show that it has receptor for relaxins (RLN1 and RLN2) which stimulates adenylate cyclase activation, substrate adhesion, and chemo migratory capacity of mononuclear leukocytes. LGR7 is critical for mediating these biological responses by use of RNA interference lentiviral short hairpin constructs. It is widely expressed in 86% of 15 primary EC tissue samples including brain, kidney, testis and endometrium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leucine-rich repeat-containing 7; leucine-rich repeat-containing G protein-coupled receptor 7; Leucine-rich repeat-containing G-protein coupled receptor 7; LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177; Relaxin family peptide receptor 1; Relaxin receptor 1; relaxin/insulin like family peptide receptor 1; unnamed protein product
Gene Aliases: Gm1018; LGR7; RXFP1; RXFPR1
UniProt ID: (Human) Q9HBX9, (Mouse) Q6R6I7
Entrez Gene ID: (Dog) 100855494, (Human) 59350, (Mouse) 381489
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
parturition
hormone-mediated signaling pathway
extracellular matrix organization
myofibroblast differentiation
lung connective tissue development
nipple morphogenesis
cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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