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Invitrogen
CDKN2C Polyclonal Antibody
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FIGURE: 1 / 3
CDKN2C Antibody (PA5-24435) in IHC (P)
Immunohistochemistry analysis of CDKN2C in formalin fixed and paraffin embedded human skeletal muscle. Samples were incubated with CDKN2C polyclonal antibody (Product # PA5-24435) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-24435
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK6 inhibitor p18; CDKN2C; cyclin-dependent inhibitor; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18-INK4c; p18-INK6; unnamed protein product
Gene Aliases: C77269; CDKN2C; CDKN6; INK4C; p18; p18-INK4C; p18-INK6; p18INK4c
UniProt ID: (Human) P42773, (Mouse) Q60772
Entrez Gene ID: (Human) 1031, (Mouse) 12580
cell proliferation
negative regulation of cell proliferation
negative regulation of cell growth
oligodendrocyte differentiation
stem cell proliferation
regulation of G1/S transition of mitotic cell cycle
negative regulation of stem cell proliferation
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
cell cycle
cell cycle arrest
negative regulation of phosphorylation
negative regulation of protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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