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Invitrogen
Contactin 2 Polyclonal Antibody
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FIGURE: 1 / 2
Contactin 2 Antibody (PA5-25742) in IHC (P)
Immunohistochemistry analysis of Contactin 2 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with Contactin 2 polyclonal antibody (Product # PA5-25742) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25742
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 293-321 amino acids from the central region of human CNTN2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axonal glycoprotein TAG-1; axonin; Axonin 1; Axonin-1; axonin-1 cell adhesion molecule; Axonin1; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin-2; Contactin2; DKFZp781D102; MGC157722; TAX-1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein; unnamed protein product
Gene Aliases: AXT; CNTN2; D130012K04Rik; EPEO5; FAME5; TAG-1; TAG1; TAX; TAX1
UniProt ID: (Human) Q02246, (Mouse) Q61330
Entrez Gene ID: (Human) 6900, (Mouse) 21367
microtubule cytoskeleton organization
neuron migration
adenosine receptor signaling pathway
response to dietary excess
reduction of food intake in response to dietary excess
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
axon guidance
axonal fasciculation
learning
adult walking behavior
positive regulation of protein processing
protein processing
cerebral cortex GABAergic interneuron migration
central nervous system neuron differentiation
central nervous system myelination
regulation of cell morphogenesis
regulation of axon diameter
neuron projection development
receptor internalization
clustering of voltage-gated potassium channels
fat cell differentiation
negative regulation of neuron differentiation
regulation of neuronal synaptic plasticity
regulation of astrocyte differentiation
synapse organization
establishment of localization in cell
positive regulation of adenosine receptor signaling pathway
dendrite self-avoidance
protein localization to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon
presynaptic membrane organization
cell-matrix adhesion
axonogenesis
regulation of cell morphogenesis involved in differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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