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Invitrogen
XDH Polyclonal Antibody
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FIGURE: 1 / 5
XDH Antibody (PA5-26285) in IHC (P)
Immunohistochemistry analysis of XDH in formalin-fixed and paraffin-embedded human hepatocarcinoma. Samples were incubated with XDH polyclonal antibody (Product # PA5-26285) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-26285
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 206-234 amino acids from the N-terminal region of human XDH
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody
Gene Aliases: XAN1; XDH; XDHA; XO; XOR; Xox-1; Xox1
UniProt ID: (Human) P47989, (Mouse) Q00519
Entrez Gene ID: (Human) 7498, (Mouse) 22436
xanthine dehydrogenase activity
xanthine oxidase activity
iron ion binding
protein binding
oxidoreductase activity
protein homodimerization activity
molybdopterin cofactor binding
metal ion binding
flavin adenine dinucleotide binding
iron-sulfur cluster binding
2 iron, 2 sulfur cluster binding
hypoxanthine dehydrogenase activity
hypoxanthine oxidase activity
FAD binding
catalytic activity
UDP-N-acetylmuramate dehydrogenase activity
electron carrier activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors
molybdenum ion binding
oxidoreductase
metabolite interconversion enzyme
allantoin metabolic process
guanine catabolic process
inosine catabolic process
deoxyinosine catabolic process
adenosine catabolic process
deoxyadenosine catabolic process
deoxyguanosine catabolic process
AMP catabolic process
IMP catabolic process
lactation
hypoxanthine catabolic process
xanthine catabolic process
iron-sulfur cluster assembly
regulation of epithelial cell differentiation
cellular amide catabolic process
GMP catabolic process
dGMP catabolic process
dAMP catabolic process
negative regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to aluminum ion
negative regulation of gene expression
bone resorption
negative regulation of endothelial cell differentiation
negative regulation of protein kinase B signaling
oxidation-reduction process
positive regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of reactive oxygen species metabolic process
negative regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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