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Invitrogen
Transthyretin Polyclonal Antibody
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FIGURE: 1 / 9
Transthyretin Antibody (PA5-27220) in WB
Western blot was performed using Anti-Transthyretin Polyclonal Antibody (Product # PA5-27220) and a 15 kDa band along with lower band as reported isoform and an uncharacterized band (*) at ~80 kDa corresponding to Transthyretin was observed in plasma sample, 2 µL lysate of Human Plasma (Lane 1) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23002) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed ... View More
Product Details
PA5-27220
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human Prealbumin Recombinant protein.
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Human plasma, Mouse liver, rat plasma.
Predicted reactivity: Mouse (81%), Rat (82%), Cat (85%), Pig (87%), Sheep (85%), Rhesus Monkey (93%), Chimpanzee (97%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Transthyretin (TTR), generally called prealbumin, is a plasma protein that plays an important role in physiology such as a transporter of hormone thyroxine and retinal-binding protein. After produced primarily in the liver, TTR is excreted into the plasma. TTR represents a disproportionate fraction (25%) of CSF protein, prompting the suggestion that it is either selectively transported across the blood-CSF barrier or synthesized de novo within the central nervous system. Transthyretin is a constituent found to the neuritic plaques, neurofibrillary tangles, and microangiopathic lesions of senile cerebral amyloid. It has been reported that more than 40 different mutations in the TTR gene associated with amyloid deposition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Amyloidosis I; ATTR; epididymis luminal protein 111; pre-albumin; Prealbumin; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; Transthyretin; TTR; unnamed protein product
Gene Aliases: AA408768; AI787086; ATTR; CTS; CTS1; D17860; HEL111; HsT2651; Lr1; PALB; prealbumin; TBPA; Tt; TTN; TTR
UniProt ID: (Human) P02766, (Mouse) P07309, (Rat) P02767
Entrez Gene ID: (Human) 7276, (Mouse) 22139, (Rat) 24856
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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