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Invitrogen
c-Cbl Polyclonal Antibody
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Product Details
PA5-27394
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human CBL. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 40% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: THP-1, 293T.
Predicted reactivity: Mouse (84%), Rhesus Monkey (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-cbl; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
Gene Aliases: C-CBL; CBL; CBL2; FRA11B; NSLL; RNF55
UniProt ID: (Human) P22681
Entrez Gene ID: (Human) 867
phosphotyrosine binding
ubiquitin-protein transferase activity
calcium ion binding
protein binding
zinc ion binding
transferase activity
SH3 domain binding
protein kinase binding
receptor tyrosine kinase binding
phosphatidylinositol 3-kinase regulatory subunit binding
cadherin binding
metal ion binding
ephrin receptor binding
ubiquitin protein ligase activity
protein tyrosine kinase binding
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
signal transduction
cell surface receptor signaling pathway
male gonad development
response to gamma radiation
response to activity
protein ubiquitination
cytokine-mediated signaling pathway
regulation of signaling
regulation of Rap protein signal transduction
response to testosterone
cellular response to platelet-derived growth factor stimulus
negative regulation of epidermal growth factor receptor signaling pathway
response to starvation
negative regulation of apoptotic process
mast cell degranulation
response to ethanol
positive regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
positive regulation of receptor-mediated endocytosis
protein autoubiquitination
positive regulation of protein kinase B signaling
ubiquitin-dependent endocytosis
cellular response to hypoxia
regulation of intracellular signal transduction
cellular response to nerve growth factor stimulus
regulation of platelet-derived growth factor receptor-alpha signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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