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Invitrogen
IFNGR1 Polyclonal Antibody
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FIGURE: 1 / 9
IFNGR1 Antibody (PA5-27841) in ICC/IF
Immunofluorescence analysis of IFNGR1 was performed using 70% confluent log phase THP-1 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with IFNGR1 Polyclonal Antibody (Product # PA5-27841) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A2... View More
Product Details
PA5-27841
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Interferon gamma Receptor 1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
13 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa, THP-1, HepG2, HepG2 membrane extract.
Predicted reactivity: Rhesus Monkey (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; cytokine receptor; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; IFNgR1; immune interferon receptor 1; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor; interferon-gamma receptor alpha chain; unnamed protein product
Gene Aliases: CD119; IFNGR; IFNGR1; IMD27A; IMD27B
UniProt ID: (Human) P15260
Entrez Gene ID: (Human) 3459
microglial cell activation
immune system process
signal transduction
JAK-STAT cascade
response to virus
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of tumor necrosis factor production
type III interferon-mediated signaling pathway
astrocyte activation
defense response to virus
interferon-gamma-mediated signaling pathway
defense response to other organism
cellular response to virus
negative regulation of beta-amyloid clearance
positive regulation of beta-amyloid formation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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