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Invitrogen
DHCR24 Polyclonal Antibody
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Product Details
PA5-27944
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Seladin 1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.29 mg/mL
Amount
129 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, H1299, mouse brain.
Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (82%), Xenopus laevis (81%), Pig (95%), Chicken (80%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol Delta-24-reductase; 3beta-hydroxysterol delta24 reductase; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; Diminuto/dwarf1 homolog; seladin 1; Seladin-1; selective AD indicator 1; unnamed protein product
Gene Aliases: DCE; DHCR24; KIAA0018; Nbla03646; seladin-1; SELADIN1
UniProt ID: (Human) Q15392, (Rat) Q5BQE6
Entrez Gene ID: (Human) 1718, (Rat) 298298
delta24(24-1) sterol reductase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
enzyme binding
peptide antigen binding
delta24-sterol reductase activity
flavin adenine dinucleotide binding
FAD binding
UDP-N-acetylmuramate dehydrogenase activity
reductase
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
Ras protein signal transduction
protein localization
steroid metabolic process
cholesterol metabolic process
negative regulation of cell proliferation
response to hormone
tissue development
sterol metabolic process
sterol biosynthetic process
male genitalia development
plasminogen activation
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
amyloid precursor protein catabolic process
skin development
membrane organization
response to oxidative stress
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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