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Invitrogen
FBXL2 Polyclonal Antibody
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Product Details
PA5-28140
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human FBXL2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.16 mg/mL
Amount
116 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, HeLa, HepG2, Raji.
Predicted reactivity: Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZP564P0622; F-box and leucine-rich repeat protein 2; F-box protein containing leucine-rich repeats; F-box protein FBL2/FBL3; F-box/LRR-repeat protein 2; FBXL2; unnamed protein product
Gene Aliases: 2810423A21Rik; FBL2; FBL3; FBXL2
UniProt ID: (Human) Q9UKC9, (Mouse) Q8BH16
Entrez Gene ID: (Human) 25827, (Mouse) 72179
proteolysis
ubiquitin-dependent protein catabolic process
protein monoubiquitination
regulation of autophagy
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of defense response
protein modification process
modulation by host of viral RNA genome replication
regulation of inflammatory response
regulation of protein kinase B signaling
negative regulation of NLRP3 inflammasome complex assembly
regulation of phosphatidylinositol 3-kinase signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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