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Invitrogen
DR3 Polyclonal Antibody
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FIGURE: 1 / 2
DR3 Antibody (PA5-28293) in IHC (P)
DR3 Polyclonal Antibody detects TNFRSF25 protein at cytosol on AGS xenograft by immunohistochemical analysis. Sample: Paraffin-embedded AGS xenograft. DR3 Polyclonal Antibody (Product # PA5-28293) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-28293
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DR3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Raji, K562.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-3; apoptosis inducing receptor; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; Death receptor 3; death receptor beta; DR3 beta; Guanine nucleotide exchange factor 720; LARD; LARD-11; NGFR family member; LARD-1a; membrane protein; LARD-1b; membrane protein; LARD-2; LARD-3; LARD-4; LARD-5; LARD-8; NGFR family member; LARD-9; NGFR family member; Lymphocyte-associated receptor of death; PH domain-containing family G member 5; Pleckstrin homology domain-containing family G member 5; Protein WSL; Protein WSL-1; RP4-650H14.2; sDR3 beta; Tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein); unnamed protein product
Gene Aliases: APO-3; APO3; DDR3; DR3; GEF720; LARD; PLEKHG5; TNFRSF12; TNFRSF25; TR3; TRAMP; UNQ455/PRO779; WSL; WSL-1; WSL-LR; WSL1
UniProt ID: (Human) Q93038
Entrez Gene ID: (Human) 8718
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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