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Invitrogen

NGF Polyclonal Antibody

Advanced Verification
2 Published Figures
2 References
View all (63) NGF antibodies

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NGF Polyclonal Antibody

Product Details

PA5-29425

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full length human NGF beta Recombinant protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.91 mg/mL

Amount

91 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546901

Product Specific Information

Recommended positive controls: NT2D1.

Predicted reactivity: Mouse (85%), Rat (85%), Dog (90%), Chimpanzee (99%), Bovine (90%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: B nerve growth factor; b-NGF; beta ngf; Beta-nerve growth factor; Beta-NGF; BetaNGF; bNGF; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta subunit; NGF b; NGF β; NGFB; NGFbeta; NGFβ; pro-nerve growth factor long; unnamed protein product; β nerve growth factor; β NGF; βNGF

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Gene Aliases: Beta-NGF; HSAN5; NGF; NGFB

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UniProt ID: (Human) P01138, (Mouse) P01139, (Rat) P25427

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Entrez Gene ID: (Human) 4803, (Mouse) 18049, (Rat) 310738

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Function(s)
enzyme inhibitor activity receptor binding nerve growth factor receptor binding protein binding growth factor activity metalloendopeptidase inhibitor activity lipid binding cysteine-type endopeptidase activator activity involved in apoptotic process transmembrane receptor protein tyrosine kinase activator activity peptidase inhibitor activity death receptor agonist activity receptor signaling protein activity molecular_function neurotrophic factor
Process(es)
signal transduction transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development circadian rhythm negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain nerve development neuron projection development positive regulation of protein ubiquitination nerve growth factor signaling pathway negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of axon extension positive regulation of Ras protein signal transduction regulation of neurotransmitter secretion neurotrophin TRK receptor signaling pathway positive regulation of collateral sprouting axon extension neuron projection morphogenesis modulation of synaptic transmission regulation of release of sequestered calcium ion into cytosol neuron apoptotic process positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade extrinsic apoptotic signaling pathway in absence of ligand cell-cell signaling memory positive regulation of cell proliferation adult locomotory behavior negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of cell growth positive regulation of protein autophosphorylation intracellular signal transduction positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of neurotrophin TRK receptor signaling pathway cellular response to acid chemical positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process inflammatory response aging response to radiation response to mechanical stimulus response to organic substance response to ozone response to organic cyclic compound response to lipopolysaccharide response to nicotine response to drug response to peptide hormone response to glucocorticoid response to electrical stimulus
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