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Invitrogen

TIP60 Polyclonal Antibody

View all (21) TIP60 antibodies

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Product Details

PA5-29457

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human TIP60. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.81 mg/mL

Amount

81 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546933

Product Specific Information

Recommended positive controls: Jurkat, Jurkat nuclear extract, mouse brain, Tip60 transfected 293T lysate.

Predicted reactivity: Mouse (100%), Rat (100%), Pig (99%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2 interacting protein; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; HIV-1 Tat interactive protein, 60kDa; K(lysine) acetyltransferase 5; K-acetyltransferase 5; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5; Tat interacting protein, 60kDa; Tat-interactive protein-60; Tip60; TIP60(HTATIP); unnamed protein product

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Gene Aliases: AI839539; CPLA2; ESA1; HTATIP; HTATIP1; KAT5; NEDFASB; PLIP; TIP; Tip55; TIP60; ZC2HC5

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UniProt ID: (Human) Q92993, (Mouse) Q8CHK4

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Entrez Gene ID: (Human) 10524, (Mouse) 81601

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Function(s)
chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding zinc ion binding H4 histone acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups H2A histone acetyltransferase activity histone H2AK5 acetyltransferase activity metal ion binding histone acetyltransferase activity (H4-K16 specific) peptide-lysine-N-acetyltransferase activity peptide 2-hydroxyisobutyryltransferase activity peptide lactyltransferase (CoA-dependent) activity peptide crotonyltransferase activity peptide butyryltransferase activity DNA-binding transcription factor binding transcription factor binding transferase activity, transferring acyl groups other than amino-acyl groups protein complex binding phospholipase binding repressing transcription factor binding histone modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation double-strand break repair via homologous recombination DNA double-strand break processing immune system process DNA repair nucleotide-excision repair double-strand break repair double-strand break repair via nonhomologous end joining chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter phosphatidylethanolamine biosynthetic process phosphatidylcholine biosynthetic process apoptotic process cellular response to DNA damage stimulus spermatid development response to ionizing radiation regulation of autophagy positive regulation of autophagy positive regulation of triglyceride biosynthetic process peptidyl-lysine acetylation triglyceride biosynthetic process neural tube development neurogenesis DNA damage response, signal transduction by p53 class mediator negative regulation of interleukin-2 production cellular response to stress sperm chromatin condensation aggrephagy cellular response to glucose starvation positive regulation of circadian rhythm regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response positive regulation of innate immune response positive regulation of regulatory T cell differentiation negative regulation of myoblast differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter attachment of mitotic spindle microtubules to kinetochore regulation of cell cycle positive regulation of mitotic sister chromatid segregation protein targeting to vacuole involved in autophagy cellular response to glucose stimulus cellular response to estradiol stimulus cellular senescence membraneless organelle assembly DNA repair-dependent chromatin remodeling cGAS/STING signaling pathway cellular response to oxygen-containing compound positive regulation of protein acetylation regulation of hematopoietic stem cell differentiation positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of double-strand break repair via homologous recombination positive regulation of aggrephagy lipid droplet disassembly protein localization to site of double-strand break negative regulation of double-strand break repair via homologous recombination regulation of double-strand break repair transcription, DNA-templated DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator chromatin modification histone acetylation regulation of growth
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