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Invitrogen
Macro H2A.2 Polyclonal Antibody
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Product Details
PA5-30648
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Macro H2A.2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: mouse brain, human H2AFY2-transfected 293T.
Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (84%), Chicken (95%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family member Y2; H2A-variant; Histone macroH2A2; histone mH2A2; mH2A2; unnamed protein product
Gene Aliases: H2AFY2; H2afy3; MACROH2A2
UniProt ID: (Mouse) Q8CCK0, (Human) Q9P0M6
Entrez Gene ID: (Mouse) 404634, (Human) 55506
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
chromatin DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
transcription regulatory region sequence-specific DNA binding
protein binding
structural constituent of chromatin
histone
negative regulation of transcription from RNA polymerase II promoter
nucleosome assembly
brain development
dosage compensation
chromatin modification
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
establishment of protein localization to chromatin
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
chromatin organization
dosage compensation by inactivation of X chromosome
heterochromatin assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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