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Invitrogen

NR1D1 Polyclonal Antibody

View all (26) NR1D1 antibodies

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Product Details

PA5-33998

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

4 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Dog, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 17 amino acid peptide from internal region of human NR1D1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551361

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%).

Target Information

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BD73; EAR-1; EAR-1R; nuclear receptor protein; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; orphan nuclear receptor; rev-erb alpha; Rev-erba; rev-erbA alpha; rev-erbA(alpha); Rev-erbA-alpha; Rev-ErbA-alpha protein; Rev-ErbAalpha; REV-ERBalpha; Reverbaalpha; RVR; unnamed protein product; V-erbA-related protein 1; V-erbA-related protein EAR-1

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Gene Aliases: A530070C09Rik; ear-1; EAR1; HREV; I79_018778; NR1D1; R75201; REV-ERBAALPHA; REVERBA; REVERBalpha; THRA1; THRAL

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UniProt ID: (Human) P20393, (Bovine) Q08E02, (Rat) Q63503, (Mouse) Q3UV55

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Entrez Gene ID: (Human) 9572, (Horse) 100054466, (Pig) 641342, (Bovine) 768225, (Dog) 100688236, (Rabbit) 100357678, (Chinese hamster) 100771327, (Rat) 252917, (Mouse) 217166

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding heme binding sequence-specific DNA binding metal ion binding E-box binding sequence-specific double-stranded DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription regulatory region DNA binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter cellular glucose homeostasis glycogen biosynthetic process regulation of transcription, DNA-templated circadian rhythm hormone-mediated signaling pathway proteasomal protein catabolic process regulation of lipid metabolic process cell differentiation intracellular steroid hormone receptor signaling pathway intracellular receptor signaling pathway protein destabilization circadian regulation of gene expression negative regulation of toll-like receptor 4 signaling pathway cholesterol homeostasis regulation of circadian sleep/wake cycle regulation of circadian rhythm negative regulation of I-kappaB kinase/NF-kappaB signaling response to leptin regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process negative regulation of inflammatory response circadian temperature homeostasis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation negative regulation of astrocyte activation positive regulation of bile acid biosynthetic process cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor negative regulation of cold-induced thermogenesis negative regulation of neuroinflammatory response negative regulation of microglial cell activation transcription, DNA-templated negative regulation of receptor biosynthetic process regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter steroid hormone mediated signaling pathway regulation of cholesterol homeostasis positive regulation of cholesterol homeostasis transcription from RNA polymerase II promoter
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