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Invitrogen
TLX Polyclonal Antibody
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Product Details
PA5-34003
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Horse,
Human,
Non-human primate,
Pig,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from N-terminal extracellular domain of human NR2E1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HTll; Nuclear receptor subfamily 2 group E member 1; nuclear receptor subfamily 2, group E, member 1; Nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; Tll
Gene Aliases: NR2E1; TLL; TLX; XTLL
UniProt ID: (Human) Q9Y466
Entrez Gene ID: (Pig) 100155153, (Human) 7101, (Dog) 475017, (Horse) 100072159, (Rabbit) 100328698, (Bovine) 528156
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
steroid hormone receptor activity
zinc ion binding
histone deacetylase binding
sequence-specific DNA binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
behavioral fear response
aggressive behavior
transcription initiation from RNA polymerase II promoter
nervous system development
visual perception
dentate gyrus development
amygdala development
olfactory bulb development
layer formation in cerebral cortex
forebrain generation of neurons
cerebral cortex neuron differentiation
anterior commissure morphogenesis
extracellular matrix organization
somatic stem cell population maintenance
social behavior
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
cell fate commitment
negative regulation of neuron differentiation
positive regulation of angiogenesis
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
negative regulation of astrocyte differentiation
regulation of dendrite morphogenesis
retina development in camera-type eye
regulation of timing of neuron differentiation
long-term synaptic potentiation
regulation of cell migration involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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