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Invitrogen
PTGER4 Polyclonal Antibody
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Product Details
PA5-34122
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 17 amino acid peptide from 3rd extracellular domain of human PTGER4 / EP4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (100%) Guinea pig (88%) Elephant, Bat, Rabbit, Horse (82%).
Target Information
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EP1; G-protein coupled receptor; PTGER4; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor
Gene Aliases: EP4; EP4R; PTGER2; PTGER4
UniProt ID: (Human) P35408
Entrez Gene ID: (Human) 5734
MAPK cascade
negative regulation of cytokine production
positive regulation of cytokine production
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JNK cascade
response to mechanical stimulus
negative regulation of integrin activation
response to lipid
response to prostaglandin E
T-helper cell differentiation
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of stress fiber assembly
bone development
ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to prostaglandin E stimulus
negative regulation of eosinophil extravasation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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