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Invitrogen
AKR1C2 Polyclonal Antibody
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FIGURE: 1 / 4
AKR1C2 Antibody (PA5-36572) in WB
Western blot analysis of AKR1C2 in Lane 1: PC12 whole cell lysate (40 µg), Lane 2: AML-12 whole cell lysate (40 µg), Lane 3: HEK293T whole cell lysate (40 µg), Lane 4: K562 whole cell lysate (40 µg), Lane 5: HeLa whole cell lysate (40 µg), Lane 6: H1792 whole cell lysate (40 µg), Lane 7: HepG2 whole cell lysate (40 µg). Samples were incubated with AKR1C2 polyclonal antibody (Product # PA5-36572) at a dilution of 1:500.
Product Details
PA5-36572
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 50-100 of human DD2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 37 kDa.
Purity is >95% by SDS-PAGE.
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are the 3 alpha- HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20 alpha- HSD catalyzes the reaction of Progesterone to the inactive form 20 alpha-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3 alpha-HSD3; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; 3-alpha-hydroxysteroid dehydrogenase; Aldo-keto reductase family 1 member C2; Aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C21; chlordecone reductase homolog; Chlordecone reductase homolog HAKRD; DD-2; DD/BABP; DD1; DD3; Dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III; Dihydrodiol dehydrogenase type 1; Dihydrodiol dehydrogenase type 3; Dihydrodiol dehydrogenase/bile acid-binding protein; HSD3-3 alpha; HSD3-alpha3; pseudo-chlordecone reductase; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase; unnamed protein product
Gene Aliases: 9430025F20Rik; AI315367; AKR1C-pseudo; AKR1C2; Akr1c21; BABP; DD; DD-2; DD/BABP; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD
UniProt ID: (Human) P52895, (Rat) Q6AYQ2, (Mouse) Q91WR5
Entrez Gene ID: (Human) 1646, (Rat) 291283, (Mouse) 77337
alditol:NADP+ 1-oxidoreductase activity
estradiol 17-beta-dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
carboxylic acid binding
bile acid binding
androsterone dehydrogenase activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity
phenanthrene 9,10-monooxygenase activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
aldo-keto reductase (NADP) activity
isocitrate dehydrogenase activity
mevaldate reductase activity
gluconate dehydrogenase activity
steroid dehydrogenase activity
epoxide dehydrogenase activity
5-exo-hydroxycamphor dehydrogenase activity
2-hydroxytetrahydrofuran dehydrogenase activity
acetoin dehydrogenase activity
phenylcoumaran benzylic ether reductase activity
D-xylose:NADP reductase activity
L-arabinose:NADP reductase activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
steroid dehydrogenase activity, acting on the CH-CH group of donors
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
3-hydroxymenthone dehydrogenase activity
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
(R)-2-hydroxyisocaproate dehydrogenase activity
L-arabinose 1-dehydrogenase (NADP+) activity
L-xylulose reductase (NAD+) activity
androsterone dehydrogenase (B-specific) activity
3-ketoglucose-reductase activity
(R)-2-hydroxyglutarate dehydrogenase activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
oxidoreductase
reductase
metabolite interconversion enzyme
alcohol metabolic process
lipid metabolic process
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
digestion
steroid metabolic process
positive regulation of cell proliferation
epithelial cell differentiation
monocarboxylic acid metabolic process
hormone metabolic process
progesterone metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
positive regulation of protein kinase B signaling
cellular response to jasmonic acid stimulus
cellular response to prostaglandin D stimulus
oxidation-reduction process
steroid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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