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Invitrogen
Phospho-VAV1 (Tyr174) Polyclonal Antibody
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Product Details
PA5-36699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide derived from human VaV1 around the phosphorylation site of Tyrosine 174
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 100 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: oncogene vav; p95; Proto-oncogene vav; unnamed protein product; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene
Gene Aliases: VAV; VAV1
UniProt ID: (Human) P15498
Entrez Gene ID: (Human) 7409, (Rat) 25156
immune response-regulating cell surface receptor signaling pathway
phagocytosis
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
T cell differentiation
neutrophil chemotaxis
intracellular signal transduction
T cell activation
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
cell development
reactive oxygen species metabolic process
regulation of cell size
response to xenobiotic stimulus
cell migration
natural killer cell activation
platelet activation
T cell costimulation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
natural killer cell mediated cytotoxicity
vascular endothelial growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
cellular response to xenobiotic stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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