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Invitrogen
MKL2 Polyclonal Antibody
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Product Details
PA5-37105
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human MRTF-B
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 118 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTA-276F8.1; gene trap insertion site 4-1; Megakaryoblastic leukemia 2; MKL and myocardin family member 2; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MKL1/myocardin like 2; MRTF-B; Myocardin-related transcription factor B; transcriptional co-activator; unnamed protein product
Gene Aliases: ENSMUSG00000075401; Gt4-1; KIAA1243; mKIAA1243; MKL2; MRTF-B; MRTFB; NPD001; RGD1560833
UniProt ID: (Human) Q9ULH7, (Mouse) P59759
Entrez Gene ID: (Human) 57496, (Mouse) 239719, (Rat) 100362470
muscle organ development
cell differentiation
positive regulation of striated muscle tissue development
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
regulation of modification of postsynaptic structure
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
in utero embryonic development
liver development
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
heart development
gene expression
regulation of gene expression
positive regulation of transcription, DNA-templated
blood vessel morphogenesis
embryonic organ development
cardiac muscle tissue development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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