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Invitrogen
LAMTOR2 Polyclonal Antibody
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Product Details
PA5-38033
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
18 amino acid peptide near the center of human LAMTOR2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A recommended positive control is HepG2 cell lysate.
At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is not expected to cross-react with other LAMTOR family proteins.
Target Information
The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling. This complex is involved in the regulation of late endosomal traffic and cellular proliferation and plays a role in cellular host defense against Salmonella infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endosomal adaptor protein p14; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; late endosomal/lysosomal MP1 interacting protein; Late endosomal/lysosomal Mp1-interacting protein; MAPBP-interacting protein; MAPKSP1 adaptor protein; mitogen activated protein binding protein interacting protein; mitogen-activated protein binding protein interacting protein; Mitogen-activated protein-binding protein-interacting protein; mitogen-activated protein-binding protein-interacting protein (MAPBPIP); Ragulator complex protein LAMTOR2; roadblock domain containing 3; Roadblock domain-containing protein 3
Gene Aliases: 2010111E04Rik; AL022628; ENDAP; HSPC003; LAMTOR2; MAPBPIP; MAPKSP1AP; P14; Rab25; Ragulator2; RGD1562501; ROBLD3
UniProt ID: (Human) Q9Y2Q5, (Mouse) Q9JHS3
Entrez Gene ID: (Human) 28956, (Mouse) 83409, (Rat) 295234
regulation of cell growth
protein localization
fibroblast migration
positive regulation of TOR signaling
TORC1 signaling
positive regulation of MAPK cascade
cellular response to amino acid stimulus
regulation of cell-substrate junction organization
protein localization to cell junction
positive regulation of intracellular signal transduction
positive regulation of TORC1 signaling
activation of MAPKK activity
cell growth
cellular protein localization
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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