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Invitrogen
HP1 alpha/beta/gamma Polyclonal Antibody
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FIGURE: 1 / 5
HP1 alpha/beta/gamma Antibody (PA5-40091) in ICC/IF
Immunofluorescence analysis of Chromobox protein homolog 5 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with HP1 alpha/beta/gamma Polyclonal Antibody (Product # PA5-40091) at 1:100 dilution in 0.1% BSA... View More
Product Details
PA5-40091
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human human HP1 beta (Heterochromatin protein 1 homolog beta).
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
50 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.05% ProClin 300, 0.05% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 25 kda chromosomal autoantigen; Antigen p25; CBX1; CBX5; chromobox homolog 1; chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox homolog 3; chromobox homolog 3 (HP1 gamma homolog, Drosophila); chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 1; Chromobox protein homolog 3; Chromobox protein homolog 5; epididymis luminal protein 25; HECH; heterochromatin protein 1 alpha; heterochromatin protein 1 gamma; Heterochromatin protein 1 homolog alpha; Heterochromatin protein 1 homolog beta; Heterochromatin protein 1 homolog gamma; heterochromatin protein 1-alpha; heterochromatin protein 1-beta; heterochromatin protein HP1 gamma; Heterochromatin protein p25; heterochromatin protein p25 beta; heterochromatin-like protein 1; HP1 alpha; HP1 alpha homolog; HP1 beta; HP1 beta homolog; HP1 gamma; HP1 gamma homolog; HP1-ALPHA; HP1Hs alpha; HP1Hsbeta; M31; mHP1(alpha); Modifier 1 protein; Modifier 2 protein; p25beta; unnamed protein product
Gene Aliases: 2610029O15Rik; C75991; CBX; Cbx-rs2; CBX1; CBX3; CBX5; E430007M08Rik; HECH; HEL25; HP1; HP1-BETA; HP1-GAMMA; HP1A; HP1alpha; HP1B; Hp1beta; HP1g; HP1gamma; HP1Hs-beta; HP1Hs-gamma; HP1Hsbeta; M31; M32; MOD1; p25beta
UniProt ID: (Human) P83916, (Human) Q13185, (Human) P45973, (Mouse) P83917, (Mouse) Q61686
Entrez Gene ID: (Human) 10951, (Human) 11335, (Human) 23468, (Mouse) 12412, (Mouse) 12417, (Mouse) 12419
chromatin binding
protein binding
enzyme binding
identical protein binding
histone methyltransferase binding
transcription cofactor binding
protein domain specific binding
protein binding, bridging
histone deacetylase binding
ribonucleoprotein complex binding
macromolecular complex binding
histone H3K9me2/3 reader activity
DNA-binding transcription factor binding
histone reader activity
protein homodimerization activity
transcription regulatory region sequence-specific DNA binding
methylated histone binding
repressing transcription factor binding
chromatin organization
chromatin remodeling
cellular response to DNA damage stimulus
heterochromatin assembly
negative regulation of transcription, DNA-templated
rhythmic process
cellular response to dexamethasone stimulus
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
negative regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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