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Invitrogen
DLX5 Polyclonal Antibody
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Product Details
PA5-40409
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human DLX5 (aa 71-120).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: NPYQYQYHGV NGSAGSYPAK AYADYSYASS YHQYGGAYNR VPSATNQPEK
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 75%
Target Information
This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: distal-less homeo box 5; Homeobox protein DLX-5; split hand/foot malformation type 1 with sensorineural hearing loss; unnamed protein product
Gene Aliases: AI385752; DLX5; SHFM1; SHFM1D
UniProt ID: (Human) P56178, (Mouse) Q9JJ45
Entrez Gene ID: (Human) 1749, (Mouse) 13395
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
HMG box domain binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
homeodomain transcription factor
skeletal system development
ossification
osteoblast differentiation
endochondral ossification
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
axonogenesis
axon guidance
cell proliferation
positive regulation of gene expression
olfactory bulb interneuron differentiation
cell differentiation
embryonic limb morphogenesis
BMP signaling pathway
epithelial cell differentiation
inner ear morphogenesis
ear development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
embryonic skeletal system development
positive regulation of epithelial cell proliferation
palate development
olfactory pit development
head development
face morphogenesis
bone morphogenesis
positive regulation of canonical Wnt signaling pathway
interneuron axon guidance
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
positive regulation of osteoblast differentiation
cellular response to BMP stimulus
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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