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Invitrogen
SOX10 Polyclonal Antibody
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FIGURE: 1 / 15
SOX10 Antibody (PA5-40697) in ICC/IF
Immunofluorescence analysis of SOX10 was performed using 70% confluent log phase A-375 cells treated with SOX10 polyclonal antibody (Product # PA5-40697). The cells were fixed with 4% paraformaldehyde for 10 Minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. cells were labeled with SOX10 polyclonal antibody (Product # PA5-40697) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain), Superclonal™ Recombinant... View More
Product Details
PA5-40697
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human SOX10
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: PGGEAEQGGT AAIQAHYKSA HLDHRHPGEG SPMSDGNPEH PSGQSHGPPT
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 86%
Target Information
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dominant megacolon, mouse, human homolog of; MGC15649; SOX10; SRY; SRY (sex determining region Y)-box 10; SRY-box 10; SRY-related HMG-box gene 10; Transcription factor SOX-10; unnamed protein product
Gene Aliases: DOM; PCWH; SOX-10; SOX10; WS2E; WS4; WS4C
UniProt ID: (Human) P56693
Entrez Gene ID: (Human) 6663
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
neural crest cell migration
morphogenesis of an epithelium
positive regulation of neuroblast proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
neuroblast proliferation
peripheral nervous system development
anatomical structure morphogenesis
negative regulation of Schwann cell proliferation
positive regulation of gene expression
oligodendrocyte development
positive regulation of gliogenesis
central nervous system myelination
cell differentiation
melanocyte differentiation
positive regulation of myelination
developmental process
lacrimal gland development
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
enteric nervous system development
digestive tract morphogenesis
developmental growth
oligodendrocyte differentiation
stem cell differentiation
morphogenesis of a branching epithelium
cellular response to progesterone stimulus
cellular response to xenobiotic stimulus
negative regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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