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Invitrogen
SPO11 Polyclonal Antibody
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Product Details
PA5-44237
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human SPO11 (aa 110-159).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: KFSLILKILS MIYKLVQSNT YATKRDIYYT DSQLFGNQTV VDNIINDISC
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 77%
Target Information
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 35; CT35; Meiotic recombination protein SPO11; MGC39953; spermatogenesis associated 43; SPO11 initiator of meiotic double stranded breaks; SPO11 meiotic protein covalently bound to DSB homolog
Gene Aliases: CT35; SPATA43; SPO11; TOPOVIA; TOPVIA
UniProt ID: (Human) Q9Y5K1
Entrez Gene ID: (Human) 23626
meiotic DNA double-strand break processing
ovarian follicle development
DNA metabolic process
synapsis
synaptonemal complex assembly
reciprocal meiotic recombination
male meiosis I
spermatogenesis
spermatid development
female gamete generation
protein localization to chromosome
meiotic DNA double-strand break formation
meiotic telomere clustering
oogenesis
meiotic cell cycle
double-strand break repair involved in meiotic recombination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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