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Invitrogen
ABI2 Polyclonal Antibody
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Product Details
PA5-45199
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human ABI2 (aa 6-55).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: MLLEEEIPGG RRALFDSYTN LERVADYCEN NYIQSADKQR ALEETKAYTT
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 85%
Target Information
ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. ABI2 is a part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. It regulates ABL1/c-Abl-mediated phosphorylation of MENA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Abelson interactor 2; Abi-2; Abi-2b; abl binding protein 3; Abl interactor 2; Abl-binding protein 3; abl-interacting protein 1 (SH3-containing protein); abl-interactor protein 2b; AblBP3; arg protein tyrosine kinase-binding protein; Arg-binding protein 1; ArgBP1; unnamed protein product
Gene Aliases: ABI-2; ABI2; ABI2B; AblBP3; AIP-1; AIP1; argBP1; ARGBPIA; argBPIB; SSH3BP2
UniProt ID: (Human) Q9NYB9
Entrez Gene ID: (Human) 10152
mitophagy
neuron migration
cytoskeleton organization
nervous system development
actin polymerization or depolymerization
positive regulation of lamellipodium assembly
cell migration
Rac protein signal transduction
peptidyl-tyrosine phosphorylation
zonula adherens assembly
cell projection morphogenesis
regulation of dendritic spine morphogenesis
lens fiber cell morphogenesis
positive regulation of Arp2/3 complex-mediated actin nucleation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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