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Invitrogen
Azurocidin Polyclonal Antibody
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Product Details
PA5-46731
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human AZU1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: QSQNPGVSTV VLGAYDLRRR ERQSRQTFSI SSMSENGYDP QQNLNDLMLL
Sequence homology: Cow: 100%; Horse: 75%; Human: 100%; Pig: 85%
Target Information
Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C. albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta 2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Azurocidin; cationic antimicrobial protein 37; Cationic antimicrobial protein CAP37; HBP; Heparin-binding protein; neutrophil azurocidin
Gene Aliases: AZAMP; AZU; AZU1; CAP37; HBP; hHBP; HUMAZUR; NAZC
UniProt ID: (Human) P20160
Entrez Gene ID: (Human) 566
microglial cell activation
proteolysis
chemotaxis
inflammatory response
phospholipase C-activating G-protein coupled receptor signaling pathway
glial cell migration
antimicrobial humoral response
positive regulation of fractalkine production
positive regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
intracellular signal transduction
monocyte extravasation
monocyte activation
defense response to bacterium
negative regulation of apoptotic process
regulation of vascular permeability
cellular extravasation
positive regulation of MHC class II biosynthetic process
positive regulation of cell adhesion
macrophage chemotaxis
positive regulation of phagocytosis
defense response to Gram-negative bacterium
induction of positive chemotaxis
protein maturation
defense response to virus
cell chemotaxis
neutrophil mediated killing of bacterium
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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