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Invitrogen
FABP5 Polyclonal Antibody
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FIGURE: 1 / 4
FABP5 Antibody (PA5-47143) in IHC (P)
Immunohistochemical analysis of FABP5 in immersion fixed paraffin-embedded sections of mouse skin (ear) tissue. Samples were incubated with FABP5 polyclonal antibody (Product # PA5-47143) using a dilution of 3 µg/mL for 1 hour at room temperature followed by Anti-Goat IgG VisUCyte™ HRP Polymer Antibody. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using... View More
Product Details
PA5-47143
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse FABP5/E-FABP Met1-Gln135
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, less than 5% cross-reactivity with recombinant mouse FABP4 and recombinant human (rh) FABP3 is observed and less than 1% cross-reactivity with recombinant rat (rr) FABP2 and rrFABP1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
FABP5 (fatty acid binding protein 5 (psoriasis-associated)) is a proteinthat in humans is encoded by theFABP5 gene, also known as PAFABP, EFABP, E-FABP, KFABP, PA-FABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog. It is a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. The PAFABP cDNA encodes a 135-amino acid protein with molecular weight 15,164. This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated inpsoriasistissue. It is though that FABPs roles include fatty acid uptake, transport, and metabolism. Kaczocha et al. (2009) identifiedFABP5and FABP7 as cytosolic proteins that transport AEA from the plasma membrane to subcellular fatty acid amide hydrolase, where it is hydrolyzed and inactivated. FABP3 did not show this specific transport function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-FABP; Cutaneous fatty acid-binding protein; DA11; E-FABP; E-FABPPAFABP; Epidermal-type fatty acid-binding protein; epithelial fatty acid-binding protein; fatty acid binding protein 5 (psoriasis-associated); Fatty acid-binding protein 5; Fatty acid-binding protein, epidermal; Keratinocyte lipid-binding protein; PA-FABP; PA-FABPepidermal; Psoriasis-associated fatty acid-binding protein homolog; unnamed protein product
Gene Aliases: C-FABP; DA11; E-FABP; EFABP; FABP5; Fabpe; KFABP; Klbp; Mal1; PA-FABP; PAFABP
UniProt ID: (Human) Q01469, (Rat) P55053, (Mouse) Q05816
Entrez Gene ID: (Human) 2171, (Rat) 140868, (Mouse) 16592
glucose metabolic process
lipid metabolic process
phosphatidylcholine biosynthetic process
lipid transport
epidermis development
negative regulation of glucose transport
fatty acid transport
long-chain fatty acid transport
regulation of prostaglandin biosynthetic process
positive regulation of peroxisome proliferator activated receptor signaling pathway
glucose homeostasis
regulation of sensory perception of pain
retrograde trans-synaptic signaling by endocannabinoid
regulation of retrograde trans-synaptic signaling by endocanabinoid
positive regulation of cold-induced thermogenesis
lipid transport across blood brain barrier
transport
response to wounding
glucose transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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