Search

  • Contáctenos
  • Orden Rápida

Invitrogen

IL-12 p40 Polyclonal Antibody

View all (38) IL-12 p40 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:

{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-47197

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
-

Neutralization (Neu)

0.05-0.25 µg/mL
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Sf 21-derived recombinant rat IL-12 p40: Met23-Ser335; p35: Arg23-Ser215

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610678

Product Specific Information

In direct ELISAs, approximatley 50% cross-reactivity with recombinant mouse IL-12 is observed, 5% cross-reactivity with recombinant human IL-12 is observed, and less than 10% cross-reactivity with recombinant feline IL-12 and recombinant canine IL-12 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.30 EU per 1 µg of the antibody by the LAL method.

Target Information

IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CLMF p35; IL-12 subunit p35; IL-12A; IL-12P40; IL12 p40; IL12A; Interleukin; interleukin-12 p40; NKSF1; RP23-388G23.1

View more View less

Gene Aliases: Il12

View more View less

Entrez Gene ID: (Rat) 64546

View more View less

Function(s)
cytokine receptor activity cytokine activity cytokine receptor binding interleukin-12 receptor binding growth factor activity interleukin-12 alpha subunit binding identical protein binding macromolecular complex binding interleukin-23 receptor binding protein heterodimerization activity
Process(es)
positive regulation of leukocyte mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host natural killer cell activation involved in immune response positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 type immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of inflammatory response to antigenic stimulus cell surface receptor signaling pathway JAK-STAT cascade cell proliferation response to UV-B cell migration cytokine-mediated signaling pathway natural killer cell activation negative regulation of interleukin-10 production negative regulation of interleukin-17 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation positive regulation of mononuclear cell proliferation positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway interleukin-23-mediated signaling pathway T-helper cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation defense response to protozoan positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of JAK-STAT cascade negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation negative regulation of protein secretion regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of NK T cell proliferation defense response to virus cellular response to lipopolysaccharide cellular response to interferon-gamma negative regulation of vascular endothelial growth factor signaling pathway negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of T-helper 17 type immune response
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support