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Invitrogen
NRXN3 Polyclonal Antibody
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FIGURE: 1 / 3
NRXN3 Antibody (PA5-47714) in IHC (P)
Immunohistochemical analysis of NRXN3 in immersion fixed paraffin-embedded sections of human brain cerebellum. Samples were incubated with NRXN3 Polyclonal Antibody (Product # PA5-47714) using a dilution of 15 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Sheep IgG HRP Secondary Antibody. Tissue was stained with DAB (brown) and counterstained with hematoxylin (blue).
Product Details
PA5-47714
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Neurexin 3/NRXN3 Ser35-Thr357
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 10% cross-reactivity with recombinant human Neurexin 1 beta is observed and less than 5% cross-reactivity recombinant rat (rr) Neurexin 1 alpha and rrNeurexin 2 beta is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: neurexin 3; Neurexin 3alpha; neurexin III; Neurexin III-alpha; Neurexin III-beta; Neurexin-3; Neurexin-3-alpha; Neurexin-3-beta; unnamed protein product
Gene Aliases: C14orf60; KIAA0743; NRXN3
UniProt ID: (Human) Q9Y4C0, (Mouse) Q8C985
Entrez Gene ID: (Human) 9369, (Mouse) 18191
angiogenesis
cell adhesion
neuron cell-cell adhesion
signal transduction
nervous system development
axon guidance
learning
adult behavior
social behavior
vocalization behavior
chemical synaptic transmission
neurotransmitter secretion
synapse assembly
positive regulation of synapse assembly
positive regulation of synapse maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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