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Invitrogen
TCEB1 Polyclonal Antibody
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FIGURE: 1 / 2
TCEB1 Antibody (PA5-50802) in IHC (P)
Immunohistochemical analysis of TCEB1 in paraffin-embedded The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using (left) TCEB1 Polyclonal Antibody (Product # PA5-50802) at a 1:40 dilution and (right) is treated with fusion protein. (Original magnification: x200).
Product Details
PA5-50802
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length fusion protein of Human TCEB1
Conjugate
Form
Liquid
Concentration
2.2 mg/mL
Amount
220 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total TCEB1 protein.
Target Information
TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EloC; elongation factor SIII p15 subunit; Elongin 15 kDa subunit; elongin C; Elongin-C; RNA polymerase II transcription factor SIII subunit C; SIII p15; Stromal membrane-associated protein SMAP1B homolog; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Transcription elongation factor B polypeptide 1; transcription elongation factor B subunit 1
Gene Aliases: 2610043E24Rik; 2610301I15Rik; AA407206; AI987979; AW049146; ELOC; SIII; TCEB1
UniProt ID: (Human) Q15369, (Rat) P83941, (Mouse) P83940
Entrez Gene ID: (Human) 6921, (Rat) 64525, (Mouse) 67923
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein ubiquitination
target-directed miRNA degradation
transcription, DNA-templated
positive regulation of transcription elongation from RNA polymerase II promoter
regulation of transcription, DNA-templated
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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