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Product Details
PA5-52286
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ADNP. Recombinant protein control fragment (Product #RP-102484).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SGSPFDPVFE VEPKISNDNP EEHVLKVIPE DASESEEKLD QKEDGSKYET IHLTEEPTKL MHNASDSEVD QDDVVEWKDG ASPSESGPGS QQVSDFEDNT CEMKPGTWSD ESSQSEDARS SKPAAKKKAT MQGDREQLKW KNSSYGKVEG
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.
Target Information
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activity-dependent neuroprotective protein; activity-dependent neuroprotector; Activity-dependent neuroprotector homeobox protein; ADNP; ADNP homeobox 1; NAP peptide; unnamed protein product
Gene Aliases: AA589558; ADNP; ADNP1; HVDAS; KIAA0784; mKIAA0784; MRD28
UniProt ID: (Human) Q9H2P0, (Mouse) Q9Z103, (Rat) Q9JKL8
Entrez Gene ID: (Human) 23394, (Mouse) 11538, (Rat) 64622
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
chromatin binding
copper ion binding
protein binding
beta-catenin binding
zinc ion binding
peptide binding
metal ion binding
beta-tubulin binding
transcription, DNA-templated
regulation of transcription, DNA-templated
short-term memory
negative regulation of gene expression
regulation of protein ADP-ribosylation
positive regulation of neuron projection development
positive regulation of cGMP biosynthetic process
negative regulation of protein binding
activation of protein kinase activity
nitric oxide homeostasis
negative regulation of neuron apoptotic process
positive regulation of axon extension
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of synaptic transmission
positive regulation of synapse assembly
response to carbohydrate
response to inorganic substance
cellular response to extracellular stimulus
estrous cycle
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
cGMP-mediated signaling
neuron differentiation
neuron apoptotic process
positive regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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